WERAM Information

Tag Content
WERAM ID WERAM-Mum-0175
Ensembl Protein ID ENSMUSP00000002305.8
Uniprot Accession Q3UWM4; KDM7A_MOUSE; A6H6E5; Q3UWN8; Q6ZPJ5; Q8C969; Q8C9E0; Q91VX8
Genbank Protein ID NP_001028602.2
Protein Name Lysine-specific demethylase 7A
Genbank Nucleotide ID NM_001033430.4
Gene Name KDM7A;KIAA1718
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000042599.8 ENSMUST00000002305.8 ENSMUSP00000002305.8
Details
Type Family Domain Substrates AA References (PMIDs)
HDM PHF2_PHF8 Jmjc H3K9; H3K27 K 20084082
Me_Reader PHD PHD-type H3K9; H3K27 K 20084082
Status Reviewed
Classification
Type Family E-value Score Start End
HDM PHF2_PHF8 1.60e-94 315.4 230 386
Me_Reader PHD 3.40e-11 44.6 38 86
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (By similarity).
Domain Profile
  HDM PHF2_PHF8
              PHF2.txt   1 fsdtklselveppdivkklslvenlwpdeavlekpkvekycligvkdsytdfhidfggasvyyhvlkgekifylirpteanlalyeawe 89 
                           fsdtk+selve+pdi++kls+ven+wpd++v++kp+v+kycl+gv+dsytdfhidfgg+sv+yhvl+gekifyli+pt++nlalye+w+
  ENSMUSP00000002305.8 230 FSDTKMSELVEVPDIARKLSWVENYWPDDSVFPKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTNENLALYESWS 318
                           79*************************************************************************************** PP
              PHF2.txt  90 sssdqsevffgdkvdkaykvvvkqgqtllipagwihavltpvdclafggnflhslniemqlrayelek 157
                           ss++qsevffgdkvdk+yk+vvkqg+tl++p+gwihavlt++dc+afggnflh+lni+mqlr+ye+ek
  ENSMUSP00000002305.8 319 SSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEK 386
                           ******************************************************************97 PP
  Me_Reader PHD
               PHD.txt  2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51
                           +C+ C+++++ +++m++Cd C+dwfH++Cv+++++++ + + ++Cp C 
  ENSMUSP00000002305.8 38 VYCV-CRQPYDVNRFMIECDVCKDWFHGSCVGVEEHHAVDIDLYHCPDCA 86
                          69*9.*****************************666665558******7 PP
Protein Sequence
(Fasta)		MAGAAAAVAA GAAAGAAAAA GSVSAPGRAS APPPPPPVYC VCRQPYDVNR FMIECDVCKD 60
WFHGSCVGVE EHHAVDIDLY HCPDCAALHG SSLMKKRRNW HRHDYTEVDD GSKPVQAGTR 120
AFVKELRSRV FPSADEIIVK MHGSQLTQRY LEKHGFDVPI MVPKLDDLGL RLPSPAFSVM 180
DVERYVGGDK VIDVIDVARQ ADSKMTLHNY VKYFMNPDRP KVLNVISLEF SDTKMSELVE 240
VPDIARKLSW VENYWPDDSV FPKPFVQKYC LMGVQDSYTD FHIDFGGTSV WYHVLWGEKI 300
FYLIKPTNEN LALYESWSSS VTQSEVFFGD KVDKCYKCVV KQGHTLFVPT GWIHAVLTSQ 360
DCMAFGGNFL HNLNIGMQLR CYEMEKRLKT PDLFKFPFFE AICWFVAKSL LETLKELKED 420
GFQPQSYLVQ GVKALHTALK LWMKKELVSE HAFEIPDNVR PGHLIKELSK VIRAIEEENG 480
KPVKSQGIPS VCPVSRPSNE ASPPYHSRRK MRKLRDHNVR TPSNLDILEL HTREVLKRLE 540
MCPWEEDLLS SKLNGKFNKH LQPSSTVPEW RAKDNDLRLL LTNGRIIKDE RQLFADRSLY 600
TADSENEEDK KPTQNANMKT EQSSGREEAE SQGSPKPLNR IFTSVRSELR SRPSEYSDGS 660
DSEDSGPDCT ALKINFATED SESSGDEKKH EITSHFKEES DIVRNLLQKS QKPSRQEIPV 720
KRECPTSTST EEEAIQGMLS MAGLHYSSCL QRQIQSTDCS GEKNSLQDPS SCHGSNPEFR 780
QLYRCNKPVE FGYHAKTEDQ DLMTSSWNKQ FDRTSRFNAQ DLSRSQKHIK KESSSEINQK 840
AQSRHCVDSN SSSIQNGKYT LNPSLVSCQI SNGSLSPERP IGETSFSMPL HPTKRPASNP 900
PPISNQATKG KRPKKGMATA KQRLGKILKL NRNGHARFFV
Nucleotide Sequence
(Fasta)		AAGACGCCGC CGCCGCAGCC GCCGCCGCTG CTGCTGCCGC CGCCGCCGCC GCCGGGGCTG 60
CTGCTCCGGC TGCTGCAGGA GGCGGCGCTG GCTGGCGGCT GCGCTCGCTC CAGTCAGCGA 120
GCGGAGGAGC GAGCGTGTGT GTGTGTTTTT TAAAGATGGC CGGAGCGGCG GCGGCGGTGG 180
CCGCGGGAGC AGCAGCTGGA GCCGCCGCGG CAGCGGGGTC GGTGTCCGCT CCGGGTCGGG 240
CCTCGGCGCC CCCTCCGCCT CCGCCCGTGT ACTGTGTATG CCGGCAGCCG TACGACGTGA 300
ACCGCTTCAT GATCGAGTGC GATGTCTGCA AGGACTGGTT CCACGGCAGC TGTGTTGGCG 360
TGGAAGAGCA TCATGCTGTG GACATTGACC TGTACCACTG CCCGGACTGT GCAGCTCTAC 420
ACGGCTCTTC CTTAATGAAG AAGAGGAGGA ACTGGCACAG GCATGACTAC ACAGAAGTGG 480
ATGATGGCTC CAAACCTGTT CAAGCTGGAA CTAGGGCCTT TGTTAAAGAA CTACGTTCTC 540
GAGTCTTCCC AAGTGCCGAT GAAATCATTG TAAAGATGCA TGGCAGTCAG CTGACACAAA 600
GATATCTGGA GAAACATGGA TTTGATGTCC CTATTATGGT CCCTAAATTA GATGACCTTG 660
GACTCAGGCT CCCTTCACCT GCTTTTTCAG TGATGGATGT GGAACGTTAT GTAGGTGGTG 720
ACAAAGTGAT AGATGTTATT GATGTGGCAA GGCAGGCGGA CAGCAAAATG ACACTTCACA 780
ATTATGTTAA ATACTTCATG AATCCTGACA GACCAAAAGT GCTAAATGTG ATCAGCCTTG 840
AATTTTCGGA TACAAAAATG TCTGAATTGG TGGAGGTTCC TGATATAGCC AGAAAACTTT 900
CATGGGTGGA AAATTACTGG CCAGATGATT CAGTCTTCCC CAAGCCCTTT GTCCAGAAAT 960
ACTGCTTAAT GGGAGTTCAA GATAGCTATA CAGATTTCCA CATTGACTTT GGTGGGACTT 1020
CAGTCTGGTA CCATGTCCTT TGGGGTGAGA AGATTTTTTA TTTGATAAAG CCAACAAATG 1080
AAAATTTGGC ACTCTATGAA TCTTGGAGTT CATCTGTGAC CCAGAGTGAG GTGTTCTTTG 1140
GAGATAAAGT AGATAAATGC TACAAATGTG TGGTAAAGCA GGGACATACT TTGTTTGTTC 1200
CTACAGGGTG GATCCATGCT GTGCTCACTT CTCAGGACTG TATGGCTTTT GGAGGGAACT 1260
TTCTGCACAA CCTCAACATT GGCATGCAGC TCAGGTGTTA TGAGATGGAA AAAAGACTAA 1320
AAACACCAGA TCTTTTCAAA TTTCCTTTCT TTGAAGCCAT ATGCTGGTTT GTAGCCAAAA 1380
GTTTGCTGGA AACCTTGAAA GAACTGAAAG AAGATGGTTT CCAGCCTCAA AGTTACTTAG 1440
TACAGGGAGT AAAAGCACTG CATACTGCTT TAAAATTATG GATGAAAAAA GAACTTGTAT 1500
CTGAACATGC CTTTGAGATT CCAGACAATG TTAGACCTGG GCATCTTATT AAGGAACTTT 1560
CTAAAGTAAT TCGAGCAATA GAGGAGGAAA ATGGCAAACC AGTTAAATCT CAGGGAATTC 1620
CTTCTGTGTG TCCAGTTTCA CGGCCTTCAA ATGAGGCATC TCCACCATAT CATTCCCGGA 1680
GAAAGATGAG GAAACTTCGA GATCATAATG TCCGAACTCC TTCTAACCTT GACATTCTTG 1740
AGCTCCATAC AAGGGAAGTC CTCAAAAGAT TAGAGATGTG TCCATGGGAG GAGGACCTAC 1800
TGAGCTCTAA ACTGAATGGA AAATTCAACA AACATCTCCA GCCATCTTCC ACAGTACCTG 1860
AGTGGAGAGC GAAAGATAAT GATCTACGAT TACTGCTGAC AAATGGAAGA ATAATTAAAG 1920
ATGAGAGACA GCTGTTTGCA GATCGAAGTC TTTATACAGC AGATAGTGAA AATGAAGAGG 1980
ACAAGAAGCC AACACAGAAT GCAAACATGA AGACAGAACA GAGCTCAGGA AGAGAGGAGG 2040
CCGAAAGTCA AGGCTCTCCC AAACCACTCA ACAGAATCTT TACAAGTGTG AGATCGGAAC 2100
TCAGGAGTAG ACCGTCAGAA TATTCTGATG GTTCTGATTC AGAAGACTCT GGACCCGACT 2160
GCACTGCACT GAAAATTAAC TTTGCCACTG AAGATTCTGA AAGTTCAGGT GATGAAAAGA 2220
AACATGAAAT AACATCACAC TTTAAAGAAG AGTCTGATAT AGTGAGGAAC CTCCTTCAGA 2280
AGAGCCAGAA GCCATCTAGA CAGGAAATCC CAGTTAAAAG GGAATGTCCT ACCTCGACGA 2340
GCACAGAGGA AGAAGCTATT CAGGGCATGC TGTCCATGGC AGGGTTGCAC TATTCCTCGT 2400
GTTTACAAAG GCAGATACAA AGCACAGATT GCAGTGGTGA GAAGAACTCT CTCCAGGATC 2460
CCAGCAGCTG CCACGGCAGT AACCCTGAGT TTAGGCAGTT GTATCGCTGC AATAAACCAG 2520
TGGAATTTGG ATACCATGCC AAGACTGAAG ATCAGGATTT GATGACTTCT TCCTGGAATA 2580
AACAGTTTGA TCGAACTTCC AGATTTAATG CTCAGGACTT AAGTAGAAGC CAGAAACACA 2640
TCAAAAAGGA AAGCTCTTCA GAAATCAATC AGAAGGCACA AAGCAGGCAT TGTGTGGACA 2700
GCAATAGCTC AAGCATTCAG AATGGAAAGT ACACGCTGAA TCCCAGCTTG GTTTCATGCC 2760
AGATAAGTAA TGGCAGCCTG AGCCCAGAAA GGCCTATTGG TGAAACTTCT TTTTCAATGC 2820
CCCTTCACCC CACCAAGAGA CCTGCATCAA ACCCACCACC TATCAGCAAC CAGGCAACAA 2880
AAGGTAAACG TCCAAAAAAA GGAATGGCAA CAGCCAAACA ACGTCTTGGG AAGATTCTGA 2940
AATTGAACAG AAATGGCCAT GCTCGCTTCT TCGTGTGACA GAGCTGCTGG TACAGTCACT 3000
CTTCCCTTTG GATGCCGGTC TCGGGGCGTG GAAGCCGGAG TTCCCCCTCC CCCTGCCTGG 3060
AGCAGTTTGT GTGTACAGTA TGAATACTGC CTGAAGAACA GAATGGACCT GATGCTGCAT 3120
TTTCACTGTG CCACACCCAC TCAGCAATAA CCCTTGGACC TGGTGGGGAG AGGAAGGCAG 3180
AGGGTAGTAG AACCTTAAAA AGAGACCTTG AACTGGAAAG GGGTCTCTTG TCAGGGCTTG 3240
AATTTAATTT TGTTGTTGGT AGTGTCTTGA TTTTATTTTT CAGTAGTAGG ATAAAGAATT 3300
ATCAATAATT TATTTAACAG ATTTTTTTTT AAAGTTAACA GCTTTTAATT TCTTTCTTTT 3360
TTTTAAAGCT ATTTATTTGG AAGATTTCTG GAGAAATATC TCACTAATTT AGATTTAAGA 3420
ATGTGAAGGT TTTTAAATTA TTTTTGATAG TGTGTGTGTT ACATGTGGAG AAGAGCCGCA 3480
GTAACAGTAG CTAGTCTGGA CTCTTAAATT TGATATTCAG GTTAAAGTCT TAAACAGGGA 3540
TTTGATGCAT TAATTATTTT AAATTAAGAT GTATATGAAA TCATTTTATT TTATATATTT 3600
CATGTGTTTT TATAAGCTAT TAGCTTCGCT TTTGCTAACA TCCAAGGTGC ATACTATAAT 3660
CCAGGTTGAT TCCCTTATAC CCTACCTTCC CTCTGCAGCC CAGTCCCCAA TGTTTTGAGA 3720
CAACCCAAGA CTCTTCTCTT TGCAGGGAAA CATGTTCATA GCCAATGTTA AAGAACCACA 3780
TAAAAGAGTC CTCATTTCTC ATTTCTTTTG ACATTGTGGT TTTCTTCTAC AAGTAACGAA 3840
TCTGGCTTGT TTTATTTTCA TTTTTCTGGG TCCCAAAGAG AACAGCTTTA ATGTCTTTTT 3900
CCTGCTTATA GGGAAAGTAT AAGTTTGGTT AAAATGTCAT GTTTGTTGTC TTTCCAAAAA 3960
CCTTTATAAT TACAGAGGGC CTTCTTCAAT ACTGCTGGTG TTGGAAGAGC CAACATCTAT 4020
CACAGGCTTT TATTATCTAG ACATCATTTT TTTAAGAAAT ACAATTTGAT TTAGGATGTT 4080
CAAATCTGCA TAAAAGCCGT AATATATACC ATATTAAGTT GTATAATAGC AAGCATGTTG 4140
GAATAGATCT TTGTGTGTGT GTGTGTGTAT GCTACTTTTT TTTTTTTAAT TTTCTGAAGA 4200
ATTAATACTG ATTTGGAGTA AAATGGGTGC TTTTGCAGTT TCTTCCATAT GTCTTGGCTA 4260
GTAGGATATG GAGGTTAAGT GACTGGGTGA ACTTTAAGAT AATAATTTAT CTCCTTTATG 4320
TACAATTTTT ACTTAAATGC AATTTTTCAG TGGCTTATAA TAGTTTTTAG TATCTCCATT 4380
TTCCCCTCAT GACATAAAAA TAAGTTGATA TTGGGGGTCT GATGATACCA CATTTTACAA 4440
ATTCCTACAA AGACAATATA GGCAAATAAC ATGAAATTTA TTTTTATGGA GAAATATGGC 4500
TATATAATGG ATTTGTTCTT TTCAATTCAG CAAGGCAGGT AGACTTTTAC TTCTGTATTA 4560
AGCATTAAGT TGAAAGGAAA TAATTATGCA CCATTATCTT TCATAGTTGC ATTCAAAATA 4620
CGTATTTCCA AAGAGAAACA TTTCTTATTC TGTCTCTTTT ACAATATTTA ATGGGATAAG 4680
GAAGTTACGA ATTCACCTTC TGGTCCAGAT TGTCTGGACC AAAGTTTCCA TTGTATTTTG 4740
AGTGTCCGGA AGAAGGATTT TTAAGGAGTT CTTCATATCT GTAGATAGCA TCCCTAGCCC 4800
CTGCCTACAC AATGCCATAA CTAGTGGAGA GAGGGATACA GTCAGCTGGT TGTTGTATTT 4860
CAACATGCAG AAATCTGAAT GTGACTGATC ACTCACCTTT CCACAATATA TCACTGTGAT 4920
GTCTTAGTTT CCTGTCTTAT TGTTAGATCA CATATTTTTA TTTGGGTTAA AAAATAATAG 4980
TGATGACTTC TTTTTCCAGT TATGATCTAG ATTTGTTTTA AACAACTCAA AATATTTTAA 5040
TTATTTTGCT TTTTGGCCTT AAAAGTTAAA ATTTATTCTT ATGAATTAAA ATTATGGCCA 5100
GTATCTTCCC TGTGCCCTTA GGCTGATGAA CACTAATTTT GGGTTGCCAC ATATGTAGTG 5160
TTTTAAATGA CAGTTTTGTG GATTCATTTT AAAAAATCAT TTTAGCCTAT TAATGGACTA 5220
AATGACAAAA CTTTTAGCCA GTTAATATAG CCACTATGAA AGAATCCAGG TATATTTCTT 5280
CACTGATAAA AATTCAGCTA CACAGCCAAT GATTTTTCTA GTCAAACTTC TTCTAAAGTT 5340
CTCCATCTGT GGTGTGTCCT TTTATCTCAT AGAAATGGCT GGACTTTGAA GTGTGACTAC 5400
TGCTAGGATC TGGGCTCAGT AATAGGTAGT CTCTGTCTTT CCCATATTCT CACAAGTAGT 5460
ATACCGCAGC TTAAGTCAGA AGATATTGGC GATAGCATTA GTTAGCTATA AGCAAATAAA 5520
ATGTGTAAAA TTGAGAAACA GCGACTTGCA CATGCAGCTT TAATAGTAGT GGTGACCCTG 5580
TCTTAATTCA GCTAAGTGAC CCTTAACCTG GGATCTACTG TACTGTAATT TTCAACACTA 5640
TAGAATATTA TGCTCCCCAG TATTGGTGAA TGGTTAGCAA TACAAAACTG GCAGCTTAGT 5700
AGTTCAGGAT CTTTGGAATA CATTGAAATT CATAAATGAA GTTCATTTTT GAAGCACACA 5760
ATTCAAATCA TTAACTCAGA CGAGACAAGT CCATTTATAT GGCTAAATAC TTAGCTTGAA 5820
TACTCTTCTG TATTTTACTA ATCCTAATTA ATTCCTTTTC CATGTATTTT ACTGTACTTA 5880
TCCATAAGAG ATCAGCAGGT ATTATCAGAC ACTCACTGAG TGCTCAGAAA TAGTGAGGAC 5940
TGTGAGGAAC CTCAAGTTCA GTTTTGTCTG TCCGTTTGTC TGTCCGTGAA GGTGTCTTCT 6000
CCAGGAGGTT TGCAGTGTTG TTTTGACTTC TAAACAAAGT TGAGCAGAAG GTGGCCCATT 6060
TGTAAACAGA ACAAACAAAA CAAAACCCAA CTTCATTAGT TTCAATGAGA TATACCACTG 6120
TAGAAGTGGA AGTGTTTAAA AACAAAATAC TCAAGTTCTT TAACATTTAA GAAAAATTCT 6180
AGCCGGGCAG TGGTGGTGCA CGCCTTTAAT CCCAGCACTT GGGAGGCAGA GGCAAGTGGA 6240
CTTCTGAGTT CGAGGCCAGC CTGGTCTACA GAGTAAATTC CAGGACAGCC AGGGCTACAC 6300
AGAGAAACCC TGTCTCAAAA AAAAAAAAAA AAAAAGAAAG AAAAGAAAAA TTCTAGCCTG 6360
GCAGTGGTGG TGCTCGCCTT TAATCTCAGC ACTTGGGAGG CAGACAGAGG CAGGCAGATT 6420
TCTGAGTTCT AGGACAGCCT AGTCTACAGA GTGAGTTCCA GGACAGCCAG GGCTACAGAG 6480
AAACCCTCTG TGGGAAAACC AGGAAAAGAA AAGAAAAATT CTACAAGTTA GTCATTTCTG 6540
TATGGTATAG CTTGGAAGGA AGCAAAAGAC CTGTATTTTA GTCCATGTTC TGCCAGTTAT 6600
CAGCCAAGCA ATGCTGAGTC AGTAGATTAT TCTGAATCTT ATCTTTTAAG TCCCAGTTTT 6660
CTTGTTTGTG ACTGTGGATT AAAAACTACT CAATGAAGAA ACAGCATTCT TCAGGTATTA 6720
TGTTATGTCA TACTTGGTTA ATTATTAAGT TACAACTGAT GATGAATGCA CCTTTCGAGA 6780
GTACTTTTAA GTAAAAATAT ACACCCAGGA CATGCTATCT AAAAATCTGA CAAATTCCTA 6840
ACAAGGTGCT GAATTAGAAT CAGGTTTTAT CCTTGAAGTG AAAGAAAAAG AAATGAGCTT 6900
CATTGTGGAC AGATGAGTGA GAGCATCCAT CAGCAAGTCA TCGATGGTTA GTTAGCACAG 6960
CAGAGGAGCT AGCTTTCGGT TTTTCTCAAA GAGGAATTAG TATAGTACTC TTCTCTATAT 7020
TTGGCCTACT CTTTGGGTAC TAAAGATAAA AGAGGTGGTA AATTTAAAAT GATTTAGCAG 7080
CTACCCATGG AGTTAGGGGA AAAATAAGGT GATGAGGAAA AACCTTTTCA AAGGCAGTTG 7140
TGGGCTAGGT ACTATGACAG CCCAGGGAGA GAGAGAAGTC AGAAGTAGTA TAGAAAGGAG 7200
ATGTGTTCAG AAATGAGTGT CCACTTGCTT CAGATGTCCT GCAGTGTGAG ACAGTCCTTG 7260
GGAATCGGTG GGAATCATGA TGGCCTAGTA TACTGCTGCC AGAGAGACAC CATAGCAAAT 7320
GTGCATTTTT GCTATTCACA TGGAAACATG AAACTTCATA ATGCAAATCT AAATCTCTCT 7380
CAAAAATTCA TTTTTCCCAT TATAAAACTA ATTGCTCCCT ATGTAAAAGA GAATGTCTCG 7440
CCTTTCATAT GTGCAAGGCC CTGGGACTTG ATCCCTAGCA CCACACAGAG ATCAAGAGGA 7500
GCTGAGGCTT CTAGACTGTT ACGGGTGTCC TAGACTTTCA TCTAATACAA TCTCAAGAAT 7560
TACACATTAC AGCTTTTGTC TAGGGAGAGC TAGCTAGTCA ATAAGGGTGA CCAGTGTAAC 7620
CCAGAGAGGA TAGATTTGCC TAGAGACACC AGTGGCTTTA GGATCTCTGG TATCTTGTTT 7680
TCTTACATGG ACCCCATTCT TTGACACTGC GGCCTCTGCT TGTCTTGTAG ACACTGTCCA 7740
TATATGTTAT TGAAGCTAGA CAAAAAGAAT TATACTCCCT GAATTGCTGT TGTGCGTAGT 7800
TACCCTCAGC CTTACTACTA ACCCTTTCCT TATTTTGCTT TCATGCTGTA AGTGAAAACA 7860
AATATTTGAT ACCCTTTCTA TAAACATTTT TTTAAAGGTT TTTAAGAAGC AAATGTCCAT 7920
TTCCAAAGCA GCTGGCATAT CATCAGTACC ACGGCTTTAT TCTTCTATAG TAAGTCTCCC 7980
CTCTTTACTG GGGAGAAAAA AAATTCTCAC TGGAGAAACC CTTAGGTTCC CTGTCACCTC 8040
TGGTGCCCTT CTAGTTTCTT AAGGCTTTGT CTTAACTGTG ATATTACACT TATGTTTAAA 8100
ACCTCTTAAA GGTGTATTCG AGGATTCTTC CAACCAATGT ATCTGCTCTG CACTATTCAT 8160
TAATGGAACC CTGGCTACCA CGTAGCCCCT GACCTCCAAG TAGTTTACCT ATGCAAGACC 8220
TGTGACACTC TGGATTCATT TTCCATTACA GAAAGCAGTC ATTAATGTGA TTTAATCATA 8280
AAGATTTGTC TTCAAGTTTT TTCCTTTTTT TTTTCAAAAT ATCAGCTATT TCCCTCTGTA 8340
TTTTTTACCA AAACAATTAT CATAAGTGCT AGAATATATA CTATTTTGCA GGAATAAAAT 8400
AACCAAGACA TAATATATTT CTTTGGTGGA TTTTGTTTTG TAAGAAATGC CAGCACTAAC 8460
TATATAGAGT TGATTCTTTG CCTAGAATAA TTTTTTTCCC TTTTAAGAGT CATAAGTAAC 8520
ATTTTATTTT CACAAAGCAT GCATATAACT TACACAATAT AGTCAGGGAC CTGAGGTGTA 8580
ACTTGCTAAG TGAACCCCAA GGTTATTTTA TCTTGCAAAA GAAACCTAAA CCAAACTAAG 8640
GGCCTTACAG TTTATGGTTA GACTGAATCA AATGCTGTAA CCTCAGTTTT TCCAAAAACA 8700
GCTCTTGACT GCACAAGCAG GTCATGCAGT TGTTAAGTAT GAAATAGCAC TGATAGGAAA 8760
TGCATGTGCA TCTTTGCAGA CTGTATTTCC TTTGGAAAAG ACTTTTCTAC TTTTAATATA 8820
ATTAAGCCAT AACAGTTTCA TGCTGTGGAA AGGATGAAAA GGTTCATTTT AAGAGATTAT 8880
ATAGTATGAA CTTTCACATT TATTGTGAAA CATCTAACTT TGCCAGTGTT CAGCAAGTTT 8940
TCTTTTGGGG TGTTGGAGGG TGGTAATGGG GAGGGGTAGT GTTGGTTTTA GGGGTTTTAA 9000
CTATGTGAAA TTTGAAATCA GGACAGTTGT TGGCTATGGT ACTTACTAGT TTTGTAGTAA 9060
TGTTTTGCTA GCCTGACTTT CCTTACTGGT TTTTATGTCC ATGGTCCCCG GTGACTGTTA 9120
CTCTTGTTTG GGGTGTGTGC ATAGTAGTGT CTCATCTGTG TGTAGGCAGT CAGTGTATGC 9180
ACACGGTGTG ACAGTGGAAC GGGGTGTGGC TGGGAGTGGG GTGCTGGAGC TTTAAGAGCA 9240
TTTGTTTTTA TTCAGAACAG TATTTCCCAT CTTTTGCCTG CAGGCAGGGA AAGTGTACAG 9300
TATTTATTTT GTTTCTGTTT TACTCTGAAT TTGTAAGTCT CTAAGTAGCT TATATTATTA 9360
TTATAGGGAA GATAAGTGAC TTGCTTAAAG TTGTATTTAG TATTCTTACT TTCTAATTTC 9420
TGTATTTTAA AATATTGAAA TTAAAATTGT ATTACTTTTG TTCTGATTTT TTTAGCACTC 9480
AGTGTATTCT TTGCTCATTT TGTCTAAAAG TATAAATGTT GAAAGTTGTA TAAAAATGTC 9540
TGAAAGAAAA AAATCTGAAT TCTATA 9567
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR003347--JmjC_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51184--JMJC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF02373--JmjC
PF00628--PHD
Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0071558--F:histone demethylase activity (H3-K27 specific)
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0035575--F:histone demethylase activity (H4-K20 specific)
GO:0005506--F:iron ion binding
GO:0035064--F:methylated histone binding
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0008270--F:zinc ion binding
GO:0071557--P:histone H3-K27 demethylation
GO:0070544--P:histone H3-K36 demethylation
GO:0033169--P:histone H3-K9 demethylation
GO:0035574--P:histone H4-K20 demethylation
GO:0030901--P:midbrain development
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Mam-0063 ENSMMUP00000010640.2 Macaca mulatta 90 0.0 1590
WERAM-Paa-0084 ENSPANP00000012302.1 Papio anubis 90 0.0 1588
WERAM-Hos-0005 ENSP00000380692.2 Homo sapiens 90 0.0 1588
WERAM-Chs-0095 ENSCSAP00000004529.1 Chlorocebus sabaeus 90 0.0 1588
WERAM-Pat-0166 ENSPTRP00000033854.5 Pan troglodytes 90 0.0 1587
WERAM-Dan-0075 ENSDNOP00000007530.3 Dasypus novemcinctus 88 0.0 1564
WERAM-Tut-0109 ENSTTRP00000009023.1 Tursiops truncatus 88 0.0 1553
WERAM-Sus-0122 ENSSSCP00000017483.2 Sus scrofa 88 0.0 1545
WERAM-Ptv-0024 ENSPVAP00000002984.1 Pteropus vampyrus 90 0.0 1524
WERAM-Ova-0130 ENSOARP00000013436.1 Ovis aries 89 0.0 1522
WERAM-Caf-0047 ENSCAFP00000005920.3 Canis familiaris 90 0.0 1522
WERAM-Nol-0019 ENSNLEP00000002239.1 Nomascus leucogenys 90 0.0 1522
WERAM-Gog-0038 ENSGGOP00000003778.2 Gorilla gorilla 90 0.0 1521
WERAM-Bot-0042 ENSBTAP00000033407.3 Bos taurus 89 0.0 1514
WERAM-Poa-0168 ENSPPYP00000020257.1 Pongo abelii 89 0.0 1512
WERAM-Mup-0034 ENSMPUP00000003537.1 Mustela putorius furo 89 0.0 1512
WERAM-Eqc-0012 ENSECAP00000002654.1 Equus caballus 89 0.0 1508
WERAM-Caj-0137 ENSCJAP00000024642.1 Callithrix jacchus 87 0.0 1507
WERAM-Aim-0207 ENSAMEP00000018869.1 Ailuropoda melanoleuca 88 0.0 1504
WERAM-Otg-0087 ENSOGAP00000006873.2 Otolemur garnettii 89 0.0 1500
WERAM-Cap-0126 ENSCPOP00000010087.2 Cavia porcellus 88 0.0 1498
WERAM-Orc-0027 ENSOCUP00000002799.2 Oryctolagus cuniculus 88 0.0 1486
WERAM-Vip-0043 ENSVPAP00000003846.1 Vicugna pacos 88 0.0 1481
WERAM-Fec-0205 ENSFCAP00000018769.1 Felis catus 90 0.0 1468
WERAM-Myl-0042 ENSMLUP00000003826.2 Myotis lucifugus 87 0.0 1465
WERAM-Mod-0119 ENSMODP00000017143.3 Monodelphis domestica 84 0.0 1458
WERAM-Tas-0064 ENSTSYP00000005800.1 Tarsius syrichta 88 0.0 1447
WERAM-Loa-0066 ENSLAFP00000004797.3 Loxodonta africana 84 0.0 1409
WERAM-Prc-0011 ENSPCAP00000000805.1 Procavia capensis 80 0.0 1346
WERAM-Sah-0159 ENSSHAP00000016739.1 Sarcophilus harrisii 83 0.0 1344
WERAM-Meg-0130 ENSMGAP00000013930.2 Meleagris gallopavo 77 0.0 1287
WERAM-Gaga-0121 ENSGALP00000020923.4 Gallus gallus 77 0.0 1287
WERAM-Anp-0159 ENSAPLP00000016291.1 Anas platyrhynchos 77 0.0 1283
WERAM-Tag-0142 ENSTGUP00000012053.1 Taeniopygia guttata 78 0.0 1280
WERAM-Pes-0093 ENSPSIP00000011413.1 Pelodiscus sinensis 77 0.0 1278
WERAM-Fia-0054 ENSFALP00000003840.1 Ficedula albicollis 77 0.0 1228
WERAM-Ora-0038 ENSOANP00000006010.2 Ornithorhynchus anatinus 77 0.0 1174
WERAM-Anc-0136 ENSACAP00000012669.2 Anolis carolinensis 68 0.0 1132
WERAM-Ect-0009 ENSETEP00000000482.1 Echinops telfairi 75 0.0 1120
WERAM-Dio-0129 ENSDORP00000012102.1 Dipodomys ordii 79 0.0 1120
WERAM-Soa-0069 ENSSARP00000006883.1 Sorex araneus 72 0.0 1107
WERAM-Mae-0053 ENSMEUP00000005244.1 Macropus eugenii 65 0.0 1060
WERAM-Lac-0177 ENSLACP00000020635.1 Latimeria chalumnae 65 0.0 1032
WERAM-Xet-0019 ENSXETP00000005738.3 Xenopus tropicalis 68 0.0 970
WERAM-Leo-0174 ENSLOCP00000020601.1 Lepisosteus oculatus 61 0.0 963
WERAM-Dar-0044 ENSDARP00000050378.6 Danio rerio 55 0.0 851
WERAM-Asm-0142 ENSAMXP00000013545.1 Astyanax mexicanus 56 0.0 837
WERAM-Tar-0195 ENSTRUP00000040079.1 Takifugu rubripes 55 0.0 821
WERAM-Orn-0001 ENSONIP00000000115.1 Oreochromis niloticus 61 0.0 767
WERAM-Orla-0169 ENSORLP00000019966.2 Oryzias latipes 61 0.0 764
WERAM-Gaa-0214 ENSGACP00000026389.1 Gasterosteus aculeatus 61 0.0 756
WERAM-Pof-0199 ENSPFOP00000016475.2 Poecilia formosa 61 0.0 754
WERAM-Gam-0031 ENSGMOP00000003440.1 Gadus morhua 67 0.0 696
WERAM-Ten-0137 ENSTNIP00000014336.1 Tetraodon nigroviridis 79 0.0 675
WERAM-Xim-0053 ENSXMAP00000004655.1 Xiphophorus maculatus 78 0.0 671
WERAM-Ere-0005 ENSEEUP00000000200.1 Erinaceus europaeus 86 0.0 671
WERAM-Ict-0112 ENSSTOP00000011474.2 Ictidomys tridecemlineatus 98 0.0 661
WERAM-Ran-0022 ENSRNOP00000040672.4 Rattus norvegicus 61 3e-158 556
WERAM-Pem-0097 ENSPMAP00000010124.1 Petromyzon marinus 64 9e-155 545
WERAM-Tub-0093 ENSTBEP00000010730.1 Tupaia belangeri 61 1e-115 415
WERAM-Mim-0110 ENSMICP00000010445.1 Microcebus murinus 56 7e-86 316
WERAM-Drm-0062 FBpp0289915 Drosophila melanogaster 42 5e-68 257
WERAM-Ocp-0120 ENSOPRP00000012395.2 Ochotona princeps 41 9e-64 243
Created Date 25-Jun-2016