| Tag |
Content |
| WERAM ID |
WERAM-Art-0123 |
| Ensembl Protein ID |
AT5G13960.1 |
| Uniprot Accession |
Q8GZB6; SUVH4_ARATH; Q9C5P3; Q9FFX9
|
| Genbank Protein ID |
NP_196900.1
|
| Protein Name |
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 |
| Genbank Nucleotide ID |
NM_121399.2
|
| Gene Name |
SUVH4;SET33;KYP;SDG33 |
| Ensembl Information |
|
| Details |
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
SUV39 |
1.00e-43 |
149.6 |
447 |
594 |
|
| Organism |
Arabidopsis thaliana |
| NCBI Taxa ID |
3702 |
Functional Description
(View)Functional Description
Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. The silencing mechanism via DNA CpNpG methylation requires the targeting of chromomethylase CMT3 to methylated histones, probably through an interaction with an HP1-like adapter. By its function, KYP is directly required for the maintenance of the DNA CpNpG and asymmetric methylation. Involved in the silencing of transposable elements. |
Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. The silencing mechanism via DNA CpNpG methylation requires the targeting of chromomethylase CMT3 to methylated histones, probably through an interaction with an HP1-like adapter. By its function, KYP is directly required for the maintenance of the DNA CpNpG and asymmetric methylation. Involved in the silencing of transposable elements.
|
| Domain Profile |
HMT SUV39
SUV39.txt 2 rLqvfktenkGwGvrclddiakgsFvciyaGeiltddeaekegleegdeyladldskesv..enlkegyesdvplssdssntrqekdkeeseyiidak 97
+L+vf++++kGw+vr+++ i++gs vc+y+G + +++++++ +++ey++++d ++++ +++ +dv++ +++ +++++d++ e++ida
AT5G13960.1 447 NLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTI---SDNEYIFEIDCQQTMqgLGGRQRRLRDVAVPMNNGVSQSSEDENAPEFCIDAG 541
79*************************************998...9***********999888999******************************** PP
SUV39.txt 98 kegnvgrflnHscspNlfvqnvfvdthdlrfprvafFaskrikagtELtwdYg 150
++gn++rf+nHsc+pNlfvq v+ +++d r+ rv++Fa+++i++++ELt+dYg
AT5G13960.1 542 STGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTYDYG 594
****************************************************6 PP
|
Protein Sequence
(Fasta) | MAGKRKRANA PDQTERRSSV RVQKVRQKAL DEKARLVQER VKLLSDRKSE ICVDDTELHE 60
KEEENVDGSP KRRSPPKLTA MQKGKQKLSV SLNGKDVNLE PHLKVTKCLR LFNKQYLLCV 120
QAKLSRPDLK GVTEMIKAKA ILYPRKIIGD LPGIDVGHRF FSRAEMCAVG FHNHWLNGID 180
YMSMEYEKEY SNYKLPLAVS IVMSGQYEDD LDNADTVTYT GQGGHNLTGN KRQIKDQLLE 240
RGNLALKHCC EYNVPVRVTR GHNCKSSYTK RVYTYDGLYK VEKFWAQKGV SGFTVYKYRL 300
KRLEGQPELT TDQVNFVAGR IPTSTSEIEG LVCEDISGGL EFKGIPATNR VDDSPVSPTS 360
GFTYIKSLII EPNVIIPKSS TGCNCRGSCT DSKKCACAKL NGGNFPYVDL NDGRLIESRD 420
VVFECGPHCG CGPKCVNRTS QKRLRFNLEV FRSAKKGWAV RSWEYIPAGS PVCEYIGVVR 480
RTADVDTISD NEYIFEIDCQ QTMQGLGGRQ RRLRDVAVPM NNGVSQSSED ENAPEFCIDA 540
GSTGNFARFI NHSCEPNLFV QCVLSSHQDI RLARVVLFAA DNISPMQELT YDYGYALDSV 600
HGPDGKVKQL ACYCGALNCR KRLY 624Protein Fasta Sequence
>AT5G13960.1|SUVH4;SET33;KYP;SDG33|Arabidopsis thaliana
MAGKRKRANAPDQTERRSSVRVQKVRQKALDEKARLVQERVKLLSDRKSEICVDDTELHEKEEENVDGSPKRRSPPKLTAMQKGKQKLSVSLNGKDVNLEPHLKVTKCLRLFNKQYLLCVQAKLSRPDLKGVTEMIKAKAILYPRKIIGDLPGIDVGHRFFSRAEMCAVGFHNHWLNGIDYMSMEYEKEYSNYKLPLAVSIVMSGQYEDDLDNADTVTYTGQGGHNLTGNKRQIKDQLLERGNLALKHCCEYNVPVRVTRGHNCKSSYTKRVYTYDGLYKVEKFWAQKGVSGFTVYKYRLKRLEGQPELTTDQVNFVAGRIPTSTSEIEGLVCEDISGGLEFKGIPATNRVDDSPVSPTSGFTYIKSLIIEPNVIIPKSSTGCNCRGSCTDSKKCACAKLNGGNFPYVDLNDGRLIESRDVVFECGPHCGCGPKCVNRTSQKRLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTADVDTISDNEYIFEIDCQQTMQGLGGRQRRLRDVAVPMNNGVSQSSEDENAPEFCIDAGSTGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTYDYGYALDSVHGPDGKVKQLACYCGALNCRKRLY |
Nucleotide Sequence
(Fasta) | ATACCAAAAA AAAGAGGAGA AAAAAAAAAC TCTCATCTTC GTCGTCTTCA CAGTTTCAAT 60
CTCGCGCTGC TTAGTCTCCT TCCGTCTCTT CTTCTCCGCT AGCTTTTCCA GGGGAAAAAG 120
AGTGATCGAT GGCTGGAAAA AGGAAACGAG CTAATGCTCC TGACCAAACA GAGCGAAGAT 180
CGAGTGTTCG GGTTCAGAAA GTGAGACAGA AAGCGTTAGA TGAGAAGGCG CGTTTAGTAC 240
AGGAGAGGGT TAAGCTCCTC AGTGACAGAA AGAGTGAAAT TTGTGTCGAT GACACTGAGT 300
TACATGAGAA AGAAGAGGAA AATGTCGATG GGAGCCCTAA ACGAAGAAGC CCTCCAAAGC 360
TAACCGCAAT GCAGAAAGGA AAGCAGAAAT TGAGTGTTTC TCTGAATGGT AAGGACGTGA 420
ACTTGGAACC TCATCTCAAA GTGACAAAGT GTCTGAGGTT ATTTAACAAG CAATATCTCC 480
TCTGTGTCCA GGCTAAGTTG AGCAGGCCTG ATTTGAAGGG TGTAACTGAG ATGATAAAAG 540
CTAAGGCGAT ATTGTACCCA AGAAAAATAA TCGGTGACCT TCCAGGTATA GACGTTGGAC 600
ACCGTTTTTT TTCAAGAGCT GAAATGTGTG CTGTAGGATT CCATAACCAT TGGCTAAATG 660
GCATTGATTA TATGTCAATG GAATACGAAA AAGAGTATAG TAACTACAAA TTACCGCTTG 720
CTGTTTCTAT TGTTATGTCG GGCCAGTACG AGGATGATCT AGACAATGCA GATACAGTGA 780
CTTACACTGG ACAGGGAGGG CATAACTTAA CTGGTAATAA ACGTCAGATA AAGGATCAAC 840
TTTTAGAACG AGGGAATTTG GCGCTAAAGC ACTGCTGCGA ATATAATGTG CCTGTCAGAG 900
TAACTCGTGG TCACAATTGC AAAAGTAGCT ATACCAAACG AGTATACACT TATGATGGAC 960
TGTACAAGGT TGAAAAGTTC TGGGCACAAA AGGGCGTTTC AGGATTTACA GTGTATAAGT 1020
ACCGACTGAA ACGATTGGAG GGGCAACCAG AACTAACTAC TGATCAGGTC AACTTTGTTG 1080
CTGGACGCAT ACCAACGAGT ACTTCAGAAA TTGAGGGTTT GGTATGTGAG GACATCTCCG 1140
GAGGGCTAGA ATTTAAGGGT ATCCCCGCCA CTAATCGTGT TGATGATTCA CCAGTTTCAC 1200
CAACATCTGG TTTCACATAC ATCAAATCTT TGATTATTGA GCCTAATGTC ATAATTCCAA 1260
AGAGTTCAAC TGGGTGTAAC TGCCGAGGCA GCTGCACTGA CTCAAAGAAA TGTGCATGTG 1320
CTAAGCTTAA TGGGGGTAAC TTTCCATATG TTGACCTTAA TGATGGCAGA TTAATTGAGT 1380
CTCGAGATGT TGTATTTGAA TGTGGTCCTC ACTGTGGGTG TGGGCCAAAA TGTGTCAACC 1440
GAACTTCTCA GAAGCGTCTA AGATTCAATC TTGAGGTTTT CCGCTCTGCA AAGAAGGGTT 1500
GGGCAGTTAG ATCATGGGAG TACATACCAG CTGGTTCACC AGTATGTGAG TACATAGGAG 1560
TTGTCAGGAG AACTGCTGAT GTGGATACTA TCTCTGACAA TGAATACATA TTTGAGATTG 1620
ACTGCCAACA GACAATGCAA GGTCTTGGTG GAAGACAGAG AAGACTAAGA GATGTTGCTG 1680
TACCAATGAA TAATGGAGTC AGTCAGAGCA GTGAAGATGA GAATGCGCCA GAGTTCTGCA 1740
TTGATGCTGG TTCAACAGGA AACTTTGCTA GGTTTATAAA TCACAGTTGT GAACCAAACC 1800
TATTTGTTCA GTGCGTCCTG AGTTCTCACC AGGATATAAG GCTTGCCCGT GTGGTTCTTT 1860
TCGCAGCTGA CAACATTTCC CCAATGCAGG AGCTCACTTA CGACTATGGA TATGCGCTTG 1920
ATAGCGTTCA TGGACCGGAT GGGAAGGTGA AGCAGCTCGC TTGCTACTGT GGAGCGCTAA 1980
ATTGTAGGAA ACGCCTTTAC TAACAAAGGC TATTGGTGAA CTTATTTTTT GGTCACTCTA 2040
TTTTGGGGAG TACATAGATA GCAACTATCT CCCAAGTGGA AGAACCCTTC ACATTTTATT 2100
TAAGGGACTT TAGCTTCTTC TGCAGCGTAC GTGCTGCCTT TTTCGGCATT GTTGTTTCCT 2160
GAATTCTATT GTTGCCATTG GCATCTTATC TATCGGGTCA ACAATATTAA TC
2213Nucleotide Fasta Sequence
>AT5G13960.1|SUV39|Arabidopsis thaliana
ATACCAAAAAAAAGAGGAGAAAAAAAAAACTCTCATCTTCGTCGTCTTCACAGTTTCAATCTCGCGCTGCTTAGTCTCCTTCCGTCTCTTCTTCTCCGCTAGCTTTTCCAGGGGAAAAAGAGTGATCGATGGCTGGAAAAAGGAAACGAGCTAATGCTCCTGACCAAACAGAGCGAAGATCGAGTGTTCGGGTTCAGAAAGTGAGACAGAAAGCGTTAGATGAGAAGGCGCGTTTAGTACAGGAGAGGGTTAAGCTCCTCAGTGACAGAAAGAGTGAAATTTGTGTCGATGACACTGAGTTACATGAGAAAGAAGAGGAAAATGTCGATGGGAGCCCTAAACGAAGAAGCCCTCCAAAGCTAACCGCAATGCAGAAAGGAAAGCAGAAATTGAGTGTTTCTCTGAATGGTAAGGACGTGAACTTGGAACCTCATCTCAAAGTGACAAAGTGTCTGAGGTTATTTAACAAGCAATATCTCCTCTGTGTCCAGGCTAAGTTGAGCAGGCCTGATTTGAAGGGTGTAACTGAGATGATAAAAGCTAAGGCGATATTGTACCCAAGAAAAATAATCGGTGACCTTCCAGGTATAGACGTTGGACACCGTTTTTTTTCAAGAGCTGAAATGTGTGCTGTAGGATTCCATAACCATTGGCTAAATGGCATTGATTATATGTCAATGGAATACGAAAAAGAGTATAGTAACTACAAATTACCGCTTGCTGTTTCTATTGTTATGTCGGGCCAGTACGAGGATGATCTAGACAATGCAGATACAGTGACTTACACTGGACAGGGAGGGCATAACTTAACTGGTAATAAACGTCAGATAAAGGATCAACTTTTAGAACGAGGGAATTTGGCGCTAAAGCACTGCTGCGAATATAATGTGCCTGTCAGAGTAACTCGTGGTCACAATTGCAAAAGTAGCTATACCAAACGAGTATACACTTATGATGGACTGTACAAGGTTGAAAAGTTCTGGGCACAAAAGGGCGTTTCAGGATTTACAGTGTATAAGTACCGACTGAAACGATTGGAGGGGCAACCAGAACTAACTACTGATCAGGTCAACTTTGTTGCTGGACGCATACCAACGAGTACTTCAGAAATTGAGGGTTTGGTATGTGAGGACATCTCCGGAGGGCTAGAATTTAAGGGTATCCCCGCCACTAATCGTGTTGATGATTCACCAGTTTCACCAACATCTGGTTTCACATACATCAAATCTTTGATTATTGAGCCTAATGTCATAATTCCAAAGAGTTCAACTGGGTGTAACTGCCGAGGCAGCTGCACTGACTCAAAGAAATGTGCATGTGCTAAGCTTAATGGGGGTAACTTTCCATATGTTGACCTTAATGATGGCAGATTAATTGAGTCTCGAGATGTTGTATTTGAATGTGGTCCTCACTGTGGGTGTGGGCCAAAATGTGTCAACCGAACTTCTCAGAAGCGTCTAAGATTCAATCTTGAGGTTTTCCGCTCTGCAAAGAAGGGTTGGGCAGTTAGATCATGGGAGTACATACCAGCTGGTTCACCAGTATGTGAGTACATAGGAGTTGTCAGGAGAACTGCTGATGTGGATACTATCTCTGACAATGAATACATATTTGAGATTGACTGCCAACAGACAATGCAAGGTCTTGGTGGAAGACAGAGAAGACTAAGAGATGTTGCTGTACCAATGAATAATGGAGTCAGTCAGAGCAGTGAAGATGAGAATGCGCCAGAGTTCTGCATTGATGCTGGTTCAACAGGAAACTTTGCTAGGTTTATAAATCACAGTTGTGAACCAAACCTATTTGTTCAGTGCGTCCTGAGTTCTCACCAGGATATAAGGCTTGCCCGTGTGGTTCTTTTCGCAGCTGACAACATTTCCCCAATGCAGGAGCTCACTTACGACTATGGATATGCGCTTGATAGCGTTCATGGACCGGATGGGAAGGTGAAGCAGCTCGCTTGCTACTGTGGAGCGCTAAATTGTAGGAAACGCCTTTACTAACAAAGGCTATTGGTGAACTTATTTTTTGGTCACTCTATTTTGGGGAGTACATAGATAGCAACTATCTCCCAAGTGGAAGAACCCTTCACATTTTATTTAAGGGACTTTAGCTTCTTCTGCAGCGTACGTGCTGCCTTTTTCGGCATTGTTGTTTCCTGAATTCTATTGTTGCCATTGGCATCTTATCTATCGGGTCAACAATATTAATC
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
--
|
| Interpro |
IPR025794--Hist-Lys_N-MeTrfase_plant
IPR003616--Post-SET_dom
IPR007728--Pre-SET_dom
IPR015947--PUA-like_domain
IPR001214--SET_dom
IPR003105--SRA_YDG
|
| PROSITE |
PS50868--POST_SET
PS50867--PRE_SET
PS51575--SAM_MT43_SUVAR39_2
PS50280--SET
PS51015--YDG
|
| Pfam |
PF05033--Pre-SET
PF02182--SAD_SRA
PF00856--SET
|
| Gene Ontology |
GO:0000775--C:chromosome, centromeric region
GO:0005634--C:nucleus
GO:0010385--F:double-stranded methylated DNA binding
GO:0046974--F:histone methyltransferase activity (H3-K9 specific)
GO:0008327--F:methyl-CpG binding
GO:0010428--F:methyl-CpNpG binding
GO:0010429--F:methyl-CpNpN binding
GO:0008270--F:zinc ion binding
GO:0051567--P:histone H3-K9 methylation
GO:0016571--P:histone methylation
GO:0010216--P:maintenance of DNA methylation
GO:0018022--P:peptidyl-lysine methylation
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
