| Tag |
Content |
| WERAM ID |
WERAM-Art-0118 |
| Ensembl Protein ID |
AT5G09230.7 |
| Uniprot Accession |
Q94AQ6; SIR4_ARATH; B9DFU7; F4KCI0; Q9FY91
|
| Genbank Protein ID |
NP_001078550.1; NP_568207.1; NP_850795.1; NP_974753.1
|
| Protein Name |
NAD-dependent protein deacylase SRT2 |
| Genbank Nucleotide ID |
NM_001085081.1; NM_120959.4; NM_180464.3; NM_203024.2
|
| Gene Name |
SRT2(SIR4);At5g09230;T5E8_30 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
SIR2 |
Deacetylase sirtuin-type |
H3K9 |
K |
26689639
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
SIR2 |
4.90e-74 |
249.7 |
87 |
369 |
|
| Organism |
Arabidopsis thaliana |
| NCBI Taxa ID |
3702 |
Functional Description
(View)Functional Description
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues (By similarity). Negatively regulates plant basal defense against plant pathogens, possibly by suppressing salicylic acid biosynthesis. |
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues (By similarity). Negatively regulates plant basal defense against plant pathogens, possibly by suppressing salicylic acid biosynthesis.
|
| Domain Profile |
HDAC SIR2
SIR2.txt 2 klakllkkskkivvltGAGiStsaGIPDFRsseGlysklkkeelpspeaifdldffrkdpkv..fyalakelyp.lgsakPtktHyflaelekkgkll 96
kl++l+++s+++++ltGAG+St++GIPD+Rs++G ys+ +++i++++f+r+++++ ++a++++ ++ +++a+P ++H++la+lek+g+++
AT5G09230.7 87 KLYRLFEQSSRLTILTGAGVSTECGIPDYRSPNGAYSS-------GFKPITHQEFTRSSRARrrYWARSYAGWRrFTAAQPGPAHTALASLEKAGRIN 177
7899*********************************9.......5899********9999889********************************** PP
SIR2.txt 97 rlytQNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkak..........................................ekvp 152
+++tQN+D+L+++ag++ +elHG+++t++C++C+ +fpr+ ++++lka +++p
AT5G09230.7 178 FMITQNVDRLHHRAGSD---PLELHGTVYTVMCLECGFSFPRDLFQDQLKAInpkwaeaiesidhgdpgseksfgmkqrpdgdieidekfweegFHIP 272
****************6...9*****************************99********************************************** PP
SIR2.txt 153 kCekCkgvlkpdivffgenlpeefleeveedlkeadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevkadkladlkllgdcdevveellkll 249
+CekCkgvlkpd++ffg+n+p+e++++++e +k++d++lvlG+Sl+ +++++l+++a+++++++++vn++e++ad+++ lk++++++e+++++l+
AT5G09230.7 273 VCEKCKGVLKPDVIFFGDNIPKERATQAMEVAKQSDAFLVLGSSLMTMSAFRLCRAAHEAGAMTAIVNIGETRADDIVPLKINARVGEILHRVLDVG 369
********************************************************************************************98865 PP
|
Protein Sequence
(Fasta) | MLSMNMRRVF GGVSTDLFPS RSMYRPLQSG GNLVMLFKGC RRFVRTTCRV SIPGGSLGNE 60
SKAPPRFLRD RKIVPDADPP NMEDIHKLYR LFEQSSRLTI LTGAGVSTEC GIPDYRSPNG 120
AYSSGFKPIT HQEFTRSSRA RRRYWARSYA GWRRFTAAQP GPAHTALASL EKAGRINFMI 180
TQNVDRLHHR AGSDPLELHG TVYTVMCLEC GFSFPRDLFQ DQLKAINPKW AEAIESIDHG 240
DPGSEKSFGM KQRPDGDIEI DEKFWEEGFH IPVCEKCKGV LKPDVIFFGD NIPKERATQA 300
MEVAKQSDAF LVLGSSLMTM SAFRLCRAAH EAGAMTAIVN IGETRADDIV PLKINARVGE 360
ILHRVLDVGS LSVPAL 376Protein Fasta Sequence
>AT5G09230.7|SRT2(SIR4);At5g09230;T5E8_30|Arabidopsis thaliana
MLSMNMRRVFGGVSTDLFPSRSMYRPLQSGGNLVMLFKGCRRFVRTTCRVSIPGGSLGNESKAPPRFLRDRKIVPDADPPNMEDIHKLYRLFEQSSRLTILTGAGVSTECGIPDYRSPNGAYSSGFKPITHQEFTRSSRARRRYWARSYAGWRRFTAAQPGPAHTALASLEKAGRINFMITQNVDRLHHRAGSDPLELHGTVYTVMCLECGFSFPRDLFQDQLKAINPKWAEAIESIDHGDPGSEKSFGMKQRPDGDIEIDEKFWEEGFHIPVCEKCKGVLKPDVIFFGDNIPKERATQAMEVAKQSDAFLVLGSSLMTMSAFRLCRAAHEAGAMTAIVNIGETRADDIVPLKINARVGEILHRVLDVGSLSVPAL |
Nucleotide Sequence
(Fasta) | GTTAGCTTCT CGGTGAAAAA CTCGATTGGT GGCTTTATTT TGATCTCAGT AGTACGATAC 60
TTTCTAGCTA GATCTTCTTC ATTGAATGCT TTCTATGAAC ATGAGAAGAG TGTTTGGAGG 120
TGTATCTACA GATTTGTTTC CGTCGCGAAG TATGTACCGG CCGCTGCAGT CTGGGGGAAA 180
CTTGGTTATG TTGTTTAAAG GATGCAGACG GTTTGTGAGA ACAACGTGTC GCGTTTCGAT 240
CCCTGGTGGT TCTTTGGGGA ATGAATCAAA AGCACCTCCA AGGTTTCTGA GGGATAGAAA 300
GATTGTTCCA GATGCTGATC CCCCCAATAT GGAAGATATC CACAAGTTGT ATCGACTTTT 360
TGAGCAAAGC TCGAGACTCA CCATCTTGAC TGGAGCTGGG GTTAGCACAG AATGTGGAAT 420
TCCGGATTAC AGAAGTCCCA ATGGAGCATA CAGTTCTGGT TTCAAACCAA TTACCCATCA 480
GGAGTTTACT CGATCAAGCC GAGCTCGTAG GCGGTATTGG GCGAGGAGTT ACGCTGGATG 540
GAGGAGGTTC ACTGCAGCAC AACCAGGACC AGCTCATACT GCTTTAGCAT CACTAGAAAA 600
AGCTGGACGA ATAAATTTTA TGATCACACA AAATGTTGAC AGGTTGCATC ATCGTGCTGG 660
GAGCGATCCA CTTGAATTAC ATGGCACAGT ATATACTGTT ATGTGCTTAG AGTGCGGCTT 720
CTCTTTTCCC CGAGACTTGT TTCAGGATCA GCTAAAAGCA ATCAATCCTA AGTGGGCTGA 780
AGCTATAGAA AGTATTGATC ATGGAGATCC AGGATCAGAG AAGAGCTTTG GCATGAAACA 840
AAGGCCTGAT GGTGATATCG AGATTGACGA AAAGTTTTGG GAAGAGGGTT TTCATATACC 900
AGTATGTGAG AAGTGCAAAG GAGTCCTAAA GCCTGATGTA ATTTTCTTTG GAGACAACAT 960
CCCGAAGGAA AGAGCTACTC AAGCAATGGA AGTTGCAAAA CAGAGCGATG CATTCCTCGT 1020
GTTGGGTTCA TCCTTAATGA CAATGTCTGC TTTTCGCCTT TGCAGAGCGG CTCATGAGGC 1080
TGGTGCTATG ACCGCAATTG TAAATATAGG CGAAACAAGA GCTGATGACA TTGTTCCATT 1140
GAAAATCAAT GCTAGGGTTG GTGAGATATT GCACAGAGTT CTTGACGTGG GATCGCTCAG 1200
TGTCCCAGCT CTCTAGCACA ATGTCCGGAT CATTTAAGTA AACTTTGGCA AGAGCTATGT 1260
TATCATTTAG ATCACCTATA TATATTATTT ATAACTAATC AAAATGAATG CTTGTATTCC 1320
TGCAACGTAT CTCAAGTTGT AAATCCAACA TCAAATAAAA GAGTAATCAA CATCAAATAA 1380
TA
1383Nucleotide Fasta Sequence
>AT5G09230.7|SIR2|Arabidopsis thaliana
GTTAGCTTCTCGGTGAAAAACTCGATTGGTGGCTTTATTTTGATCTCAGTAGTACGATACTTTCTAGCTAGATCTTCTTCATTGAATGCTTTCTATGAACATGAGAAGAGTGTTTGGAGGTGTATCTACAGATTTGTTTCCGTCGCGAAGTATGTACCGGCCGCTGCAGTCTGGGGGAAACTTGGTTATGTTGTTTAAAGGATGCAGACGGTTTGTGAGAACAACGTGTCGCGTTTCGATCCCTGGTGGTTCTTTGGGGAATGAATCAAAAGCACCTCCAAGGTTTCTGAGGGATAGAAAGATTGTTCCAGATGCTGATCCCCCCAATATGGAAGATATCCACAAGTTGTATCGACTTTTTGAGCAAAGCTCGAGACTCACCATCTTGACTGGAGCTGGGGTTAGCACAGAATGTGGAATTCCGGATTACAGAAGTCCCAATGGAGCATACAGTTCTGGTTTCAAACCAATTACCCATCAGGAGTTTACTCGATCAAGCCGAGCTCGTAGGCGGTATTGGGCGAGGAGTTACGCTGGATGGAGGAGGTTCACTGCAGCACAACCAGGACCAGCTCATACTGCTTTAGCATCACTAGAAAAAGCTGGACGAATAAATTTTATGATCACACAAAATGTTGACAGGTTGCATCATCGTGCTGGGAGCGATCCACTTGAATTACATGGCACAGTATATACTGTTATGTGCTTAGAGTGCGGCTTCTCTTTTCCCCGAGACTTGTTTCAGGATCAGCTAAAAGCAATCAATCCTAAGTGGGCTGAAGCTATAGAAAGTATTGATCATGGAGATCCAGGATCAGAGAAGAGCTTTGGCATGAAACAAAGGCCTGATGGTGATATCGAGATTGACGAAAAGTTTTGGGAAGAGGGTTTTCATATACCAGTATGTGAGAAGTGCAAAGGAGTCCTAAAGCCTGATGTAATTTTCTTTGGAGACAACATCCCGAAGGAAAGAGCTACTCAAGCAATGGAAGTTGCAAAACAGAGCGATGCATTCCTCGTGTTGGGTTCATCCTTAATGACAATGTCTGCTTTTCGCCTTTGCAGAGCGGCTCATGAGGCTGGTGCTATGACCGCAATTGTAAATATAGGCGAAACAAGAGCTGATGACATTGTTCCATTGAAAATCAATGCTAGGGTTGGTGAGATATTGCACAGAGTTCTTGACGTGGGATCGCTCAGTGTCCCAGCTCTCTAGCACAATGTCCGGATCATTTAAGTAAACTTTGGCAAGAGCTATGTTATCATTTAGATCACCTATATATATTATTTATAACTAATCAAAATGAATGCTTGTATTCCTGCAACGTATCTCAAGTTGTAAATCCAACATCAAATAAAAGAGTAATCAACATCAAATAATA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0520--NAD
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0862--Zinc
--
|
| Interpro |
IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR026587--Sirtuin_class_II
IPR026590--Ssirtuin_cat_dom
|
| PROSITE |
PS50305--SIRTUIN
|
| Pfam |
PF02146--SIR2
|
| Gene Ontology |
GO:0005759--C:mitochondrial matrix
GO:0005634--C:nucleus
GO:0016787--F:hydrolase activity
GO:0046872--F:metal ion binding
GO:0070403--F:NAD+ binding
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
