| Tag |
Content |
| WERAM ID |
WERAM-Art-0086 |
| Ensembl Protein ID |
AT3G49660.1 |
| Uniprot Accession |
Q9M2Z2; WDR5A_ARATH
|
| Genbank Protein ID |
NP_190535.1
|
| Protein Name |
COMPASS-like H3K4 histone methylase component WDR5A |
| Genbank Nucleotide ID |
NM_114826.3
|
| Gene Name |
WDR5a;At3g49660;T16K5.10 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
WD40 |
WD1-7 |
H3K4me2 |
K |
19567704
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
WD40 |
6.40e-112 |
374.9 |
22 |
314 |
|
| Organism |
Arabidopsis thaliana |
| NCBI Taxa ID |
3702 |
Functional Description
(View)Functional Description
Forms multiple COMPASS-like complexes involved in histone methylation by interacting with different histone H3 'Lys-4' methyltransferases such as ATX1, SDG14 or SDG16 (PubMed:21423667). Binds to target loci chromatin, increasing H3K4 trimethylation and causing activation of the gene (PubMed:19567704). Upregulates FLC and MAF4 expression to delay flowering (PubMed:19567704). |
Forms multiple COMPASS-like complexes involved in histone methylation by interacting with different histone H3 'Lys-4' methyltransferases such as ATX1, SDG14 or SDG16 (PubMed:21423667). Binds to target loci chromatin, increasing H3K4 trimethylation and causing activation of the gene (PubMed:19567704). Upregulates FLC and MAF4 expression to delay flowering (PubMed:19567704).
|
| Domain Profile |
Me_Reader WD40
WD40.txt 1 dhekelsavkfepaseegaslvaatvgseavtvydcqtq..geikllqkykghdeefysvawtadsnkrhslLasAgdrglirlldveagqcikvlvg 96
+h++++s+vkf s++g+ l+a++++++++++y+++t ++++++q+++gh++++++va+++d++ +++sA+d+++++l+dve+g++ik+l+g
AT3G49660.1 22 SHNRAVSSVKF---SSDGR-LLASASADKTIRTYTINTIndPIAEPVQEFTGHENGISDVAFSSDAR----FIVSASDDKTLKLWDVETGSLIKTLIG 111
69*********...*****.******************9999*************************....9************************** PP
WD40.txt 97 HknaiaelkFsPkdenlllsaSfdkrvrlWdiktdklkkifeahsdevldvdydlrgslivScgmdgslkiWdvrskrrvcevklvddenpeksnrrV 194
H+n++++++F+P+ +n+++s+Sfd++vr+Wd++t+k++k+++ahsd+v++vd++++gslivS+++dg+++iWd s +++c+++l+ddenp+ V
AT3G49660.1 112 HTNYAFCVNFNPQ-SNMIVSGSFDETVRIWDVTTGKCLKVLPAHSDPVTAVDFNRDGSLIVSSSYDGLCRIWD--SGTGHCVKTLIDDENPP-----V 201
*************.***********************************************************..*****************.....* PP
WD40.txt 195 dcvrfs.ngdlilsgsldntivlWdirkikqsevavvvLkrfeyskteiyyislsfsvdnkkilvsgdedgkvyvwdlsveaalkakelllklgkvta 291
++vrfs ng++il+g+ldnt++lW+i+++k +Lk+++++ +++y+is++fsv+n+k++vsg+ed++v++w+l+ +k+ll+kl+++t+
AT3G49660.1 202 SFVRFSpNGKFILVGTLDNTLRLWNISSAK-------FLKTYTGHVNAQYCISSAFSVTNGKRIVSGSEDNCVHMWELN------SKKLLQKLEGHTE 286
******************************.......******************************************......************* PP
WD40.txt 292 kimqtsvspnesiiiltaltddnivkiWdr 321
++m+++++p+e++i++++l d++v+iW++
AT3G49660.1 287 TVMNVACHPTENLIASGSL--DKTVRIWTQ 314
*******************..*******97 PP
|
Protein Sequence
(Fasta) | MAEEIPATAS FTPYVHSQTL TSHNRAVSSV KFSSDGRLLA SASADKTIRT YTINTINDPI 60
AEPVQEFTGH ENGISDVAFS SDARFIVSAS DDKTLKLWDV ETGSLIKTLI GHTNYAFCVN 120
FNPQSNMIVS GSFDETVRIW DVTTGKCLKV LPAHSDPVTA VDFNRDGSLI VSSSYDGLCR 180
IWDSGTGHCV KTLIDDENPP VSFVRFSPNG KFILVGTLDN TLRLWNISSA KFLKTYTGHV 240
NAQYCISSAF SVTNGKRIVS GSEDNCVHMW ELNSKKLLQK LEGHTETVMN VACHPTENLI 300
ASGSLDKTVR IWTQKKE 317Protein Fasta Sequence
>AT3G49660.1|WDR5a;At3g49660;T16K5.10|Arabidopsis thaliana
MAEEIPATASFTPYVHSQTLTSHNRAVSSVKFSSDGRLLASASADKTIRTYTINTINDPIAEPVQEFTGHENGISDVAFSSDARFIVSASDDKTLKLWDVETGSLIKTLIGHTNYAFCVNFNPQSNMIVSGSFDETVRIWDVTTGKCLKVLPAHSDPVTAVDFNRDGSLIVSSSYDGLCRIWDSGTGHCVKTLIDDENPPVSFVRFSPNGKFILVGTLDNTLRLWNISSAKFLKTYTGHVNAQYCISSAFSVTNGKRIVSGSEDNCVHMWELNSKKLLQKLEGHTETVMNVACHPTENLIASGSLDKTVRIWTQKKE |
Nucleotide Sequence
(Fasta) | CTCTCCTTTA GTTAGACAAA GCCTCCTTTC CCAAAACCCT AAAATCAGCC AAATTCAAAT 60
TCCGCTAACC AATTTCCATG GCAGAGGAAA TTCCAGCAAC AGCATCATTC ACTCCATACG 120
TCCATTCACA AACTCTAACA TCTCACAATC GCGCCGTCTC CTCCGTGAAA TTCTCCTCCG 180
ATGGACGTCT CCTCGCATCC GCCTCCGCCG ACAAAACAAT CCGCACTTAC ACAATCAACA 240
CCATTAACGA TCCAATCGCC GAGCCCGTAC AAGAATTCAC CGGCCATGAA AACGGTATCT 300
CCGATGTTGC ATTCTCTTCA GACGCGAGGT TTATAGTCTC AGCTTCCGAT GACAAAACCT 360
TAAAGCTATG GGACGTTGAA ACTGGTTCAT TGATCAAGAC GCTTATTGGA CACACTAATT 420
ACGCCTTCTG TGTCAATTTC AATCCTCAAT CAAATATGAT TGTATCTGGT TCGTTTGATG 480
AAACTGTTCG GATCTGGGAT GTCACTACTG GAAAGTGTTT GAAAGTTCTT CCCGCGCATT 540
CTGATCCTGT TACTGCTGTT GATTTTAATA GAGATGGGTC TCTCATTGTT TCGAGTAGCT 600
ATGATGGGTT GTGTCGTATA TGGGATTCTG GGACTGGTCA TTGTGTGAAA ACTCTGATTG 660
ATGATGAGAA TCCTCCTGTT TCGTTTGTTA GATTCTCTCC TAATGGCAAG TTTATCCTCG 720
TTGGTACACT TGATAACACG CTGAGGTTGT GGAACATTTC GTCTGCTAAG TTCCTCAAAA 780
CATACACTGG CCACGTGAAC GCACAGTATT GCATTTCCTC TGCGTTCTCC GTCACAAATG 840
GAAAGCGAAT AGTCAGTGGA TCCGAGGACA ACTGTGTACA CATGTGGGAG CTAAACTCCA 900
AGAAACTGCT ACAGAAACTT GAGGGTCATA CTGAGACCGT CATGAACGTA GCATGCCACC 960
CGACAGAGAA CTTGATCGCA TCAGGCTCGC TCGACAAGAC AGTAAGGATT TGGACACAGA 1020
AGAAAGAATA AATCATCACT CTCTCTCTTC AGAAATCAAA CATGTAGGTA CATGCCACCT 1080
TCTTCATGCA GTAATCATCT GTTGCTTACT AAGCTTGTTA GATTGATTCT AGCCTCATTA 1140
TGTAAAAGTC TAATTTTTGT TTGGTGTAAG GGAAGTGCAA CAGACTGTTC TAAACTTGTA 1200
ATAGTTCTCT GTGTGACTCA GAACTATTTA GGTAGGTCTT AAGGCAAAGA CTCCTGCAAG 1260
TGCAAAGGCA TTTGAGAGAA TGAACACAAA TCTTCATAGG TTTACCCTTT ACTCATTGTA 1320
TCTATTAAGC TGATGCAATG CTTCACCAAT ACTATTGGTT ATAAAGTAGT TTCAGGATTG 1380
AAAATTG
1388Nucleotide Fasta Sequence
>AT3G49660.1|WD40|Arabidopsis thaliana
CTCTCCTTTAGTTAGACAAAGCCTCCTTTCCCAAAACCCTAAAATCAGCCAAATTCAAATTCCGCTAACCAATTTCCATGGCAGAGGAAATTCCAGCAACAGCATCATTCACTCCATACGTCCATTCACAAACTCTAACATCTCACAATCGCGCCGTCTCCTCCGTGAAATTCTCCTCCGATGGACGTCTCCTCGCATCCGCCTCCGCCGACAAAACAATCCGCACTTACACAATCAACACCATTAACGATCCAATCGCCGAGCCCGTACAAGAATTCACCGGCCATGAAAACGGTATCTCCGATGTTGCATTCTCTTCAGACGCGAGGTTTATAGTCTCAGCTTCCGATGACAAAACCTTAAAGCTATGGGACGTTGAAACTGGTTCATTGATCAAGACGCTTATTGGACACACTAATTACGCCTTCTGTGTCAATTTCAATCCTCAATCAAATATGATTGTATCTGGTTCGTTTGATGAAACTGTTCGGATCTGGGATGTCACTACTGGAAAGTGTTTGAAAGTTCTTCCCGCGCATTCTGATCCTGTTACTGCTGTTGATTTTAATAGAGATGGGTCTCTCATTGTTTCGAGTAGCTATGATGGGTTGTGTCGTATATGGGATTCTGGGACTGGTCATTGTGTGAAAACTCTGATTGATGATGAGAATCCTCCTGTTTCGTTTGTTAGATTCTCTCCTAATGGCAAGTTTATCCTCGTTGGTACACTTGATAACACGCTGAGGTTGTGGAACATTTCGTCTGCTAAGTTCCTCAAAACATACACTGGCCACGTGAACGCACAGTATTGCATTTCCTCTGCGTTCTCCGTCACAAATGGAAAGCGAATAGTCAGTGGATCCGAGGACAACTGTGTACACATGTGGGAGCTAAACTCCAAGAAACTGCTACAGAAACTTGAGGGTCATACTGAGACCGTCATGAACGTAGCATGCCACCCGACAGAGAACTTGATCGCATCAGGCTCGCTCGACAAGACAGTAAGGATTTGGACACAGAAGAAAGAATAAATCATCACTCTCTCTCTTCAGAAATCAAACATGTAGGTACATGCCACCTTCTTCATGCAGTAATCATCTGTTGCTTACTAAGCTTGTTAGATTGATTCTAGCCTCATTATGTAAAAGTCTAATTTTTGTTTGGTGTAAGGGAAGTGCAACAGACTGTTCTAAACTTGTAATAGTTCTCTGTGTGACTCAGAACTATTTAGGTAGGTCTTAAGGCAAAGACTCCTGCAAGTGCAAAGGCATTTGAGAGAATGAACACAAATCTTCATAGGTTTACCCTTTACTCATTGTATCTATTAAGCTGATGCAATGCTTCACCAATACTATTGGTTATAAAGTAGTTTCAGGATTGAAAATTG
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0853--WD repeat
--
|
| Interpro |
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
|
| PROSITE |
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
|
| Pfam |
PF00400--WD40
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0048188--C:Set1C/COMPASS complex
GO:0042393--F:histone binding
GO:0008168--F:methyltransferase activity
GO:0010228--P:vegetative to reproductive phase transition of meristem
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
