| Tag |
Content |
| WERAM ID |
WERAM-Art-0040 |
| Ensembl Protein ID |
AT2G19670.1 |
| Uniprot Accession |
O82210; ANM12_ARATH
|
| Genbank Protein ID |
NP_179557.1
|
| Protein Name |
Probable protein arginine N-methyltransferase 1.2 |
| Genbank Nucleotide ID |
NM_127525.4
|
| Gene Name |
PRMT12;ANM12 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HMT |
PRMT |
PRMT-type |
H4R3 |
R |
17666011
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
PRMT |
1.20e-129 |
432.8 |
46 |
346 |
|
| Organism |
Arabidopsis thaliana |
| NCBI Taxa ID |
3702 |
Functional Description
(View)Functional Description
Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain. Type I arginine methyltransferase active on both histones and non-histone proteins. Mediates the methylation of MED36A. |
Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain. Type I arginine methyltransferase active on both histones and non-histone proteins. Mediates the methylation of MED36A.
|
| Domain Profile |
HMT PRMT
PRMT.txt 2 qqylqslselLesgvyeemlkDevrtdaYreailknktllkdkvvldvGaGtGiLslfaakagarkvyavekspmakvarkvvkvnglkdrvtvikgk 99
++y++s+s++ g++eemlkD vrt++Y+++i+knk+l+kdk+vldvGaGtGiLslf+akaga++vyave+s+ma++a+++vk+ng++d++tv+kgk
AT2G19670.1 46 DYYFDSYSHF---GIHEEMLKDVVRTKSYQDVIYKNKFLIKDKIVLDVGAGTGILSLFCAKAGAAHVYAVECSQMADTAKEIVKSNGFSDVITVLKGK 140
89********...************************************************************************************* PP
PRMT.txt 100 veelelpkekvDiivSEllgsfllnEsllpsvlhardkfLkddglslPdkatlyvapiedtklykeekaefwksvygvdlsclekaaikeqfesplVd 197
+ee+elp++kvD+i+SE++g+fll+E++l++vl+ar+k+L+d+g++lPdka+lyv++ied + yk++k+efw++vyg+d+sc++++ai+e plVd
AT2G19670.1 141 IEEIELPVPKVDVIISEWMGYFLLYENMLDTVLYARNKWLVDGGIVLPDKASLYVTAIEDAH-YKDDKVEFWDDVYGFDMSCIKRRAITE----PLVD 233
**************************************************************.***************************....9*** PP
PRMT.txt 198 tldkekllsepkkiftfdiskakesdeerelslelevkrnaslhglaayFdvqft.sektvvlStaPetkspathWkqavlyledpltvkegekis.. 292
t+d +++++++k+++t+disk++++d++++++++l+++rn+++h+l+ayFdv+ft ++k++++St P ks+athWkq+vlyled+lt++ege+i+
AT2G19670.1 234 TVDGNQIVTDSKLLKTMDISKMAAGDASFTAPFKLVAQRNDHIHALVAYFDVSFTmCHKKMGFSTGP--KSRATHWKQTVLYLEDVLTICEGETITgs 329
*******************************************************************..***************************** PP
PRMT.txt 293 illlarkknsrdvdyel 309
++++++kkn+rdvd++l
AT2G19670.1 330 MTIAQNKKNPRDVDIKL 346
***************98 PP
|
Protein Sequence
(Fasta) | MTSTENNNNG SDETQTTKLH FEDADESMHD GDDNNADVAD DITSADYYFD SYSHFGIHEE 60
MLKDVVRTKS YQDVIYKNKF LIKDKIVLDV GAGTGILSLF CAKAGAAHVY AVECSQMADT 120
AKEIVKSNGF SDVITVLKGK IEEIELPVPK VDVIISEWMG YFLLYENMLD TVLYARNKWL 180
VDGGIVLPDK ASLYVTAIED AHYKDDKVEF WDDVYGFDMS CIKRRAITEP LVDTVDGNQI 240
VTDSKLLKTM DISKMAAGDA SFTAPFKLVA QRNDHIHALV AYFDVSFTMC HKKMGFSTGP 300
KSRATHWKQT VLYLEDVLTI CEGETITGSM TIAQNKKNPR DVDIKLSYSL NGQHCNISRT 360
HFYKMR 366Protein Fasta Sequence
>AT2G19670.1|PRMT12;ANM12|Arabidopsis thaliana
MTSTENNNNGSDETQTTKLHFEDADESMHDGDDNNADVADDITSADYYFDSYSHFGIHEEMLKDVVRTKSYQDVIYKNKFLIKDKIVLDVGAGTGILSLFCAKAGAAHVYAVECSQMADTAKEIVKSNGFSDVITVLKGKIEEIELPVPKVDVIISEWMGYFLLYENMLDTVLYARNKWLVDGGIVLPDKASLYVTAIEDAHYKDDKVEFWDDVYGFDMSCIKRRAITEPLVDTVDGNQIVTDSKLLKTMDISKMAAGDASFTAPFKLVAQRNDHIHALVAYFDVSFTMCHKKMGFSTGPKSRATHWKQTVLYLEDVLTICEGETITGSMTIAQNKKNPRDVDIKLSYSLNGQHCNISRTHFYKMR |
Nucleotide Sequence
(Fasta) | AAACCCTAAA TCTTTTTGCT TATTCGAATC TGTTAGCCAT CCAAAACCTC TCTCTTTGCC 60
GCAAAAAATG ACTAGTACGG AGAACAACAA CAACGGCTCT GATGAAACTC AGACGACGAA 120
GTTACACTTC GAGGATGCTG ATGAATCAAT GCACGATGGA GATGACAACA ATGCCGATGT 180
TGCTGATGAC ATTACCAGCG CCGATTACTA CTTCGATTCT TACTCTCATT TCGGTATTCA 240
TGAAGAAATG TTAAAGGATG TAGTGAGGAC AAAGAGTTAT CAAGATGTTA TTTACAAGAA 300
CAAGTTTCTT ATCAAGGACA AAATTGTTCT TGATGTTGGA GCTGGAACTG GAATCTTGTC 360
TCTCTTCTGT GCTAAAGCAG GAGCAGCTCA CGTTTACGCA GTTGAGTGTT CTCAAATGGC 420
TGACACAGCA AAGGAGATTG TTAAGTCGAA TGGATTCTCA GATGTTATAA CGGTTTTGAA 480
AGGGAAGATT GAGGAGATCG AACTTCCAGT TCCTAAAGTG GATGTGATTA TCTCTGAATG 540
GATGGGTTAC TTTCTGTTGT ATGAAAATAT GCTTGACACC GTCTTGTATG CTCGCAATAA 600
ATGGCTTGTT GATGGTGGAA TTGTTCTACC AGATAAAGCT TCTCTTTATG TTACTGCCAT 660
TGAGGATGCT CATTATAAAG ACGACAAAGT AGAGTTTTGG GACGACGTGT ATGGGTTTGA 720
CATGTCGTGC ATCAAGAGAA GAGCAATTAC AGAACCGCTT GTTGACACCG TTGATGGTAA 780
CCAAATCGTG ACTGATAGCA AGCTGCTGAA GACAATGGAT ATCTCTAAGA TGGCTGCTGG 840
AGATGCTTCC TTCACAGCTC CGTTTAAGCT CGTCGCACAA CGAAATGACC ATATCCATGC 900
CCTTGTAGCC TACTTCGATG TGTCATTCAC TATGTGTCAC AAGAAGATGG GTTTCTCAAC 960
AGGACCGAAA TCGCGGGCTA CGCATTGGAA ACAAACTGTG CTGTACCTGG AAGATGTGTT 1020
AACCATATGC GAGGGTGAAA CAATCACAGG AAGCATGACC ATTGCACAAA ACAAAAAGAA 1080
TCCCAGAGAC GTCGACATAA AGCTCAGCTA TTCTTTGAAC GGCCAACATT GCAATATCTC 1140
AAGGACCCAC TTCTATAAGA TGCGCTAAAA GCTCTCAGAG GATGTAAAAT CCCCCACAAG 1200
TACCTTTCAT CATCTTGAGG CTGAGATGGA CAAATCTCAT TTGTATCTCT ACTGTTTCCA 1260
TTATTGCTGC TTATGTTTCA GAATTAGATA TTAACCATCT CTCTCTTTCT CTCTCACTGT 1320
GCGTCTCTTC CTCTATGATA GTTTCTTGTT CCTCTCGACC
1361Nucleotide Fasta Sequence
>AT2G19670.1|PRMT|Arabidopsis thaliana
AAACCCTAAATCTTTTTGCTTATTCGAATCTGTTAGCCATCCAAAACCTCTCTCTTTGCCGCAAAAAATGACTAGTACGGAGAACAACAACAACGGCTCTGATGAAACTCAGACGACGAAGTTACACTTCGAGGATGCTGATGAATCAATGCACGATGGAGATGACAACAATGCCGATGTTGCTGATGACATTACCAGCGCCGATTACTACTTCGATTCTTACTCTCATTTCGGTATTCATGAAGAAATGTTAAAGGATGTAGTGAGGACAAAGAGTTATCAAGATGTTATTTACAAGAACAAGTTTCTTATCAAGGACAAAATTGTTCTTGATGTTGGAGCTGGAACTGGAATCTTGTCTCTCTTCTGTGCTAAAGCAGGAGCAGCTCACGTTTACGCAGTTGAGTGTTCTCAAATGGCTGACACAGCAAAGGAGATTGTTAAGTCGAATGGATTCTCAGATGTTATAACGGTTTTGAAAGGGAAGATTGAGGAGATCGAACTTCCAGTTCCTAAAGTGGATGTGATTATCTCTGAATGGATGGGTTACTTTCTGTTGTATGAAAATATGCTTGACACCGTCTTGTATGCTCGCAATAAATGGCTTGTTGATGGTGGAATTGTTCTACCAGATAAAGCTTCTCTTTATGTTACTGCCATTGAGGATGCTCATTATAAAGACGACAAAGTAGAGTTTTGGGACGACGTGTATGGGTTTGACATGTCGTGCATCAAGAGAAGAGCAATTACAGAACCGCTTGTTGACACCGTTGATGGTAACCAAATCGTGACTGATAGCAAGCTGCTGAAGACAATGGATATCTCTAAGATGGCTGCTGGAGATGCTTCCTTCACAGCTCCGTTTAAGCTCGTCGCACAACGAAATGACCATATCCATGCCCTTGTAGCCTACTTCGATGTGTCATTCACTATGTGTCACAAGAAGATGGGTTTCTCAACAGGACCGAAATCGCGGGCTACGCATTGGAAACAAACTGTGCTGTACCTGGAAGATGTGTTAACCATATGCGAGGGTGAAACAATCACAGGAAGCATGACCATTGCACAAAACAAAAAGAATCCCAGAGACGTCGACATAAAGCTCAGCTATTCTTTGAACGGCCAACATTGCAATATCTCAAGGACCCACTTCTATAAGATGCGCTAAAAGCTCTCAGAGGATGTAAAATCCCCCACAAGTACCTTTCATCATCTTGAGGCTGAGATGGACAAATCTCATTTGTATCTCTACTGTTTCCATTATTGCTGCTTATGTTTCAGAATTAGATATTAACCATCTCTCTCTTTCTCTCTCACTGTGCGTCTCTTCCTCTATGATAGTTTCTTGTTCCTCTCGACC
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
|
| Interpro |
IPR025799--Arg_MeTrfase
IPR029063--SAM-dependent_MTases
|
| PROSITE |
PS51678--SAM_MT_PRMT
|
| Pfam |
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0008469--F:histone-arginine N-methyltransferase activity
GO:0035242--F:protein-arginine omega-N asymmetric methyltransferase activity
GO:0034969--P:histone arginine methylation
GO:0019919--P:peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
