Rattus norvegicus      HMT      SET1

※ SET1 family introduction

    SET1: The SET1 gene in the budding yeast Saccharomyces cerevisiae was discovered by several laboratories as encoding the first known H3K4 methyltransferase, a catalytic function performed through its conserved SET domain. Yeast Set1, like its orthologs in higher eukaryotes (SET1A/B in humans), is recruited to chromatin by the serine 5-phosphorylated C-terminal domain of RNA polymerase II (pol II). This interaction with the initiating form of pol II results in the occupancy of Set1 near the 5’-end of active genes, which correlates closely with the peak of H3K4me3. (1)

    In metazoans, SET1A/B proteins seem to function analogously to yeast Set1 in performing the majority of transcription-coupled H3K4 methylation found at active genes, presumably through co-transcriptional recruitment. Unlike their yeast counterpart, human SET1A/B proteins are also recruited to chromatin via an interaction with non-methylated CpG island sequences, mediated by the SET1A/B-associated protein CFP1.

Reference
1. Ernst P, Vakoc CR.WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics.2012;11(3):217-226. PMID: 22652693.



There are 19 genes.  Reviewed (0 or Unreviewed (19

No.StatusWERAM IDGene/Alias Name
1
WERAM-Ran-0009
Setd8
2
WERAM-Ran-0012
Setd1b
3
WERAM-Ran-0036
Ezh2
4
WERAM-Ran-0049
Kmt2c
5
WERAM-Ran-0100
Kmt2a
6
WERAM-Ran-0102
Suv39h2
7
WERAM-Ran-0103
Whsc1l1
8
WERAM-Ran-0107
Nsd1
9
WERAM-Ran-0133
Ezh1
10
WERAM-Ran-0136
Ash1l
11
WERAM-Ran-0141
Setd2
12
WERAM-Ran-0180
AABR07010705.1
13
WERAM-Ran-0186
Whsc1
14
WERAM-Ran-0187
Suv39h1l1
15
WERAM-Ran-0219
RGD1561853
16
WERAM-Ran-0224
AABR07040393.1
17
WERAM-Ran-0237
AC111812.1
18
WERAM-Ran-0238
Kmt2b
19
WERAM-Ran-0263
Prkag1