Canis familiaris      HDAC      Class-I

※ Class-I family introduction

    Class-I: Class I HDACs share homology with the yeast Rpd3. This class includes HDACs 1, 2, 3, and 8, and its members are expressed ubiquitously in humans. Members 1, 2, and 3 are found in multi-protein repressor complexes in the nucleus, where they regulate gene expression. HDAC8 is found in both the nucleus and cytoplasm, and while it has not been found in any multi-protein complexes, it has been described to be involved in transcriptional repression. (1)

Reference
1. Koeneke, E., Witt, O., & Oehme, I.HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities. Cells.2015;4(2):135-168. PMID: 25915736.



There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusWERAM IDGene/Alias Name
1
WERAM-Caf-0004
HDAC10
2
WERAM-Caf-0031
HDAC9
3
WERAM-Caf-0048
HDAC2
4
WERAM-Caf-0054
HDAC11
5
WERAM-Caf-0075
HDAC3
6
WERAM-Caf-0101
HDAC7
7
WERAM-Caf-0116
HDAC1
8
WERAM-Caf-0133
HDAC4
9
WERAM-Caf-0149
HDAC5
10
WERAM-Caf-0161
HDAC6
11
WERAM-Caf-0183
HDAC8